Senior Director, Clinical Pharmacology

Contineum Therapeutics • Full-time • Remote (San Diego, California, United States) • 4w ago

Company Overview:
Contineum Therapeutics (Nasdaq: CTNM) is a clinical-stage biopharmaceutical company pioneering novel, oral small molecule therapies for NI&I indications with significant unmet need. Contineum is advancing a pipeline of internally-developed programs with multiple drug candidates now in clinical trials. PIPE-791 is an LPA1 receptor antagonist in clinical development for idiopathic pulmonary fibrosis and chronic pain. PIPE-307 is a selective inhibitor of the M1 receptor in clinical development for relapsing-remitting multiple sclerosis and major depressive disorder. For more information, please visit www.contineum-tx.com.

Role Overview:

Contineum Therapeutics is seeking a Senior Director, Clinical Pharmacology to lead the development and execution of clinical pharmacology strategies across the company’s portfolio. Reporting to a senior leader in Clinical Development, this role will be responsible for establishing and delivering clinical pharmacology approaches, including PK, PK/PD, and exposure-response analyses, to inform dose selection, study design, and regulatory strategy from IND throughout clinical development. The Senior Director will integrate preclinical and clinical pharmacology data to enable data-driven advancement of programs through key development milestones. The individual will combine strategic leadership with direct execution, including responsibility for the design, oversight and interpretation of early-phase clinical studies (e.g., first-in-human SAD/MAD, hAME, and relevant DDI studies). The individual will serve as a cross-functional leader and subject matter expert in clinical pharmacology, partnering closely with a highly matrixed R & D team to ensure timely, high-quality program delivery. This role is expected to operate with a high degree of autonomy and scientific judgment, contributing meaningfully to program‑level development decisions.

This role can be hybrid from San Diego, CA or fully remote from the West Coast of the United States. Preference for San Diego, CA or Seattle, WA based candidates.

Serve as the clinical pharmacology subject matter expert, leading clinical pharmacology strategy across multiple programs from IND through proof-of-concept and into mid-stage clinical development

Develop and execute integrated clinical pharmacology plans, including the design and oversight of early-phase clinical studies (e.g., FIH SAD/MAD, food effect, DDI, organ impairment, TQT)
Lead PK/PD and exposure-response strategy, leveraging non-compartmental analyses, population PK, and modeling to inform dose selection, study design, and benefit–risk assessments
Translate nonclinical DMPK and translational data into clinical development strategies, partnering with Research, Translational Medicine, and Biomarker teams to integrate mechanistic and pharmacodynamic insights
Author and review clinical pharmacology components of regulatory documents (e.g., INDs, MAAs, protocols, study reports, IBs, and briefing packages) and support global regulatory interactions
Collaborate with Biometrics and external modeling partners to ensure robust statistical analysis plans, TLFs, and modeling outputs that support high-quality development decisions (e.g., dose selection/rationale in future clinical studies)
Provide clinical pharmacology leadership in internal governance forums, contributing to development strategy, program prioritization, and risk-benefit decision-making
Manage external CROs and vendors, ensuring high-quality execution, regulatory compliance, adherence to timelines, and alignment with internal standards
Ensure compliance with GCP, ICH guidelines, and internal SOPs, partnering with Quality Assurance on SOP development and continuous process improvement
Represent Clinical Pharmacology within cross-functional asset teams, collaborating closely with Clinical, Regulatory, Nonclinical, CMC, and other stakeholders to ensure aligned and integrated development strategies

Education and Experience Requirements:

Ph.D. or PharmD in relevant fields such as pharmaceutical sciences or clinical pharmacology

8+ years of relevant industry experience in clinical pharmacology and/or pharmacometrics in the biotech or pharmaceutical industry, including all aspects of drug development
Deep understanding of pharmacokinetics, pharmacodynamics, drug metabolism, and exposure-response principles
Proven success in the design and execution of early-phase clinical studies, including healthy volunteer studies
Expert knowledge of clinical pharmacology regulatory requirements, with experience supporting IND, NDA/MAA/NDS submissions and engaging with health authorities
Experience managing external clinical pharmacology and modeling resources, including CROs and consultants

We offer a competitive total compensation package and work in a supportive team environment. The anticipated salary range for candidates who will work in San Diego, CA or Seattle, WA, is $270,000 - $294,000 annually. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc. Contineum offers competitive compensation and benefits, including:

90% employer-covered benefits
Flexible PTO
A very generous holiday schedule that includes a week off in August and time off around the winter holidays
A well-stocked kitchen with snacks and beverages
Additional benefits include the opportunity for annual bonuses, stock options, an Employee Stock Purchase Program, and a 401(k) with an employer match.
The comprehensive wellness program includes medical, dental, vision, and LTD coverage.

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